RESUMEN
: We performed an observational prospective monocentric study in patients living with HIV (PLWH) diagnosed with COVID-19. Fifty-four PLWH developed COVID-19 with 14 severe (25.9%) and five critical cases (9.3%), respectively. By multivariate analysis, age, male sex, ethnic origin from sub-Saharan Africa and metabolic disorder were associated with severe or critical forms of COVID-19. Prior CD4 T cell counts did not differ between groups. No protective effect of a particular antiretroviral class was observed.
Asunto(s)
Infecciones por Coronavirus/epidemiología , Infecciones por VIH/complicaciones , Neumonía Viral/epidemiología , Adulto , África del Sur del Sahara/etnología , Antirretrovirales/uso terapéutico , Recuento de Linfocito CD4 , COVID-19 , Infecciones por Coronavirus/etnología , Femenino , Francia/epidemiología , Infecciones por VIH/tratamiento farmacológico , Humanos , Modelos Logísticos , Masculino , Enfermedades Metabólicas/complicaciones , Persona de Mediana Edad , Análisis Multivariante , Pandemias , Neumonía Viral/etnología , Estudios Prospectivos , Medición de Riesgo , Factores de RiesgoRESUMEN
For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.